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Physicochemical characterizations of piroxicam-poloxamer solid dispersion
1College of Pharmacy, Chonnam National University, South Korea. shinsc@chonnam.chonnam.ac.kr
Pharmaceutical Development and Technology
|April 29, 1998
Summary
This study developed a poloxamer gel for topical piroxicam delivery, enhancing its solubility and demonstrating interactions between the drug and poloxamer for improved formulation.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
Background:
- Topical drug delivery systems require efficient formulations for enhanced therapeutic outcomes.
- Piroxicam is a non-steroidal anti-inflammatory drug (NSAID) commonly used for pain and inflammation.
Purpose of the Study:
- To develop an efficient topical delivery system for piroxicam using poloxamer gel.
- To investigate the physicochemical behavior of piroxicam within poloxamer formulations.
Main Methods:
- Poloxamer 407 gelation properties and piroxicam solubility were assessed.
- Interactions between piroxicam and poloxamer were analyzed using X-ray diffractometry (XRD), Infrared (IR) spectroscopy, and Differential Thermal Analysis (DTA).
Main Results:
- Poloxamer 407 solutions exhibited gelation at concentrations above 15% (w/w).
- Aqueous solubility of piroxicam increased approximately 11-fold at 22.5% (w/w) poloxamer 407.
- XRD indicated no crystalline piroxicam in solid dispersions, and IR spectroscopy revealed functional group associations between piroxicam and poloxamer.
Conclusions:
- Poloxamer gel formulations are effective for topical piroxicam delivery.
- The enhanced solubility and observed interactions suggest a promising solid dispersion or coprecipitate system for piroxicam.