Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Genetic therapy

R D Simari1, E G Nabel

  • 1Department of Internal Medicine, University of Michigan, Ann Arbor 48109-0644, USA.

Seminars in Interventional Cardiology : SIIC
|March 1, 1996
PubMed
Summary

Vascular gene transfer introduces foreign DNA into vessel walls for therapeutic insights and potential treatments. Research focuses on safe vectors and delivery for cardiovascular diseases like restenosis and occlusive vascular disease.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Corrigendum to "Scaffolds for tissue engineering of cardiac valves" [Acta Biomater. 10 (2014) 2877-2893].

Acta biomaterialia·2017
Same author

Scaffolds for tissue engineering of cardiac valves.

Acta biomaterialia·2014
Same author

Methods for liposome-mediated gene transfer to the arterial wall.

Methods in molecular medicine·2014
Same author

Methods for liposome-mediated gene transfer to tumor cells in vivo.

Methods in molecular medicine·2014
Same author

Gene transfer and cardiovascular disease.

Trends in cardiovascular medicine·2011
Same author

Effect of enhanced external counterpulsation on circulating CD34+ progenitor cell subsets.

International journal of cardiology·2010

Area of Science:

  • Cardiovascular Research
  • Molecular Biology
  • Gene Therapy

Background:

  • Vascular gene transfer involves introducing foreign DNA into vascular cells.
  • Gene expression has been observed in various arterial conditions, including normal, injured, and atherosclerotic states.
  • This technique offers insights into gene functions in both normal physiology and disease pathology.

Purpose of the Study:

  • To explore the role of specific genes in vascular health and disease through gene transfer.
  • To evaluate the potential of vascular gene transfer as a therapeutic strategy for cardiovascular diseases.
  • To assess the safety and efficacy of different vectors and delivery systems for intravascular gene transfer.

Main Methods:

  • Demonstration of recombinant gene expression in vascular cells of normal, injured, and atherosclerotic arteries.
  • Evaluation of viral and non-viral vectors for gene delivery.
  • Assessment of various intravascular delivery catheters for clinical applicability.

Main Results:

  • Successful expression of foreign DNA in vascular cells has been achieved.
  • Gene transfer has provided valuable insights into the function of specific genes in vascular states.
  • Current applications focus on preventing restenosis and inducing angiogenesis.

Conclusions:

  • Vascular gene transfer is a promising field for understanding and treating cardiovascular diseases.
  • Development requires safe and effective vectors and delivery systems.
  • Key applications include preventing post-injury restenosis and treating occlusive vascular disease through angiogenesis induction.

Related Experiment Videos