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Subcutaneous T-cell lymphoma: report of two cases
F Wasik1, T Kołodziej, M Jeleń
1Department of Dermatology, University School of Medicine, Wrocław, Poland.
Summary
Two patients with subcutaneous T-cell lymphoma and fever showed histopathology consistent with cytophagic histiocytic panniculitis. One patient died, while the other responded to chemotherapy (cyclophosphamide, doxorubicin, vincristine, prednisone).
Area of Science:
- Dermatology
- Oncology
- Pathology
Background:
- Subcutaneous T-cell lymphoma is a rare malignancy.
- Cytophagic histiocytic panniculitis is an inflammatory condition often associated with hemophagocytic syndrome.
Observation:
- Two patients presented with subcutaneous nodules and fever.
- Histopathology revealed lobular, histiocytic panniculitis with immature T-cells and 'bean bag' cells.
Findings:
- The findings were consistent with subcutaneous T-cell lymphoma associated with cytophagic histiocytic panniculitis.
- One patient developed fatal hemophagocytic syndrome, while the other achieved remission with CHOP chemotherapy.
Implications:
- This case series highlights the association between subcutaneous T-cell lymphoma and cytophagic histiocytic panniculitis.
- Early diagnosis and appropriate treatment, such as CHOP chemotherapy, may improve outcomes.