Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Scopolamine's effect on passive avoidance behavior in immature rats

L M Wilson, D C Riccio

    Developmental Psychobiology
    |May 1, 1976
    PubMed
    Summary

    Scopolamine impairs passive avoidance learning in young rats, suggesting a role for cholinergic systems in memory development. This effect varies with age and dosage.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Challenges of Twin Pregnancy: Helping parents adjust.

    Canadian family physician Medecin de famille canadien·2011
    Same author

    Analysis of gene expression during the onset of muscle hypertrophy in callipyge lambs.

    Animal genetics·2007
    Same author

    Role of inertia in two-dimensional deformation and breakdown of a droplet.

    Physical review. E, Statistical, nonlinear, and soft matter physics·2003
    Same author

    Myocardial infarction during adenosine stress test.

    Heart (British Cardiac Society)·2002
    Same author

    Structure of linkage disequilibrium and phenotypic associations in the maize genome.

    Proceedings of the National Academy of Sciences of the United States of America·2001
    Same author

    MK-801 induced retrieval, but not acquisition, deficits for passive avoidance conditioning.

    Pharmacology, biochemistry, and behavior·2001

    Area of Science:

    • Neuroscience
    • Developmental Psychology
    • Pharmacology

    Background:

    • The cholinergic system plays a crucial role in cognitive functions, including memory.
    • Understanding the developmental trajectory of memory and the influence of neurochemical agents is vital.

    Purpose of the Study:

    • To investigate the effects of scopolamine hydrobromide on passive avoidance (PA) learning and memory in developing rats.
    • To explore age-dependent differences in scopolamine's impact on memory formation.

    Main Methods:

    • Male albion rats (15-30 days old) were administered scopolamine hydrobromide or saline.
    • Animals were trained and tested on a black-white passive avoidance task.
    • Retention was assessed after a 1-week interval.

    Main Results:

    • Scopolamine (1.0 mg/kg) impaired PA learning in 18-, 21-, and 30-day-old rats.
    • A higher dose (2.0 mg/kg) was needed to impair 15-day-old rats.
    • No state-dependent effects were observed during retention testing.

    Conclusions:

    • Cholinergic systems appear to inhibit passive avoidance responding in preweanling and postweanling rats.
    • Age significantly influences the impact of scopolamine on memory acquisition.

    Related Experiment Videos