Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Immunological status in tuberous sclerosis

S P Galant, G W Fowler, L Amin

    Developmental Medicine and Child Neurology
    |August 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Cadherin 26 is an alpha integrin-binding epithelial receptor regulated during allergic inflammation.

    Mucosal immunology·2017
    Same author

    Religious Scholars' Attitudes and Views on Ethical Issues Pertaining to Pre-Implantation Genetic Diagnosis (PGD) in Malaysia.

    Journal of bioethical inquiry·2016
    Same author

    Gender differences in the impact of poverty on health: disparities in risk of diabetes-related amputation.

    Diabetic medicine : a journal of the British Diabetic Association·2014
    Same author

    Potential of cyclodextrin complexation and liposomes in topical delivery of ketorolac: in vitro and in vivo evaluation.

    AAPS PharmSciTech·2008
    Same author

    Therapy for patients with high grade astrocytoma using intraarterial chemotherapy and radiation therapy.

    Cancer·2000
    Same author

    Interaction of Shigella flexneri IpaC with model membranes correlates with effects on cultured cells.

    Infection and immunity·2000
    Same journal

    Predictive ability of the Hammersmith Neonatal Neurological Examination for identifying severe neurodevelopmental impairment in infants born very preterm.

    Developmental medicine and child neurology·2026
    Same journal

    Neuropathic pain in cerebral palsy and related genetic conditions: A scoping review of prevalence, characteristics, and management.

    Developmental medicine and child neurology·2026
    Same journal

    Hammersmith Infant Neurological Examination global scores for predicting neurodevelopmental outcomes after 2 years of age: A systematic review and meta-analysis.

    Developmental medicine and child neurology·2026
    Same journal

    Seizure worsening and sodium channel blockers in HCN1-related epilepsies: A case series.

    Developmental medicine and child neurology·2026
    Same journal

    What is the impact of childhood-onset disability research - and what should it be?

    Developmental medicine and child neurology·2026
    Same journal

    Sleep disturbances in children with cerebral palsy, their siblings, and parents: A qualitative descriptive study.

    Developmental medicine and child neurology·2026
    See all related articles

    Tuberous sclerosis patients showed elevated serum IgM but no immune deficiency. Neoplasia was only observed in tuberous sclerosis patients, suggesting a link between this genetic disorder and cancer development.

    Area of Science:

    • Immunology
    • Oncology
    • Genetics

    Background:

    • Tuberous sclerosis (TS) is a genetic disorder affecting multiple organs.
    • The immune system's role in TS and its association with neoplasia require further investigation.

    Purpose of the Study:

    • To investigate cellular and humoral immunity in institutionalized patients with tuberous sclerosis.
    • To compare infection incidence and neoplasia development between TS patients and controls.
    • To examine lymphoid organ pathology in TS.

    Main Methods:

    • Comparative analysis of immune function (cellular and humoral) in 10 TS patients and 10 matched controls.
    • Review of infection types and incidence, tumor occurrence, and medication.
    • Histopathological examination of lymph nodes, spleen, and thymus.

    Related Experiment Videos

    Main Results:

    • Elevated serum IgM levels were found in TS patients.
    • No significant differences in cellular or humoral immunity, or infection rates, were observed between groups.
    • Neoplasia was exclusively identified in the tuberous sclerosis group.
    • Lymphoid organs (lymph nodes, spleen, thymus) showed no morphological or histological abnormalities.

    Conclusions:

    • Tuberous sclerosis is not associated with primary immunodeficiency.
    • The increased incidence of neoplasia in TS patients warrants further research into the underlying mechanisms.
    • Immune surveillance may play a role in the development of malignancy in TS.