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Bladder dysfunction and neuropathy in diabetes

A C Buck, P I Reed, Y K Siddiq

    Diabetologia
    |July 1, 1976
    PubMed
    Summary
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    Diabetic neuropathy frequently causes bladder dysfunction and peripheral nerve damage, even in early stages. This study highlights the high incidence of subclinical neuropathy in diabetes mellitus patients.

    Area of Science:

    • Neurology
    • Urology
    • Endocrinology

    Background:

    • Diabetes mellitus is a systemic disease with potential complications affecting multiple organ systems.
    • Autonomic and peripheral neuropathy are known complications of diabetes, impacting various bodily functions.
    • Assessing neuropathy in diabetic patients is crucial for understanding disease progression and management.

    Observation:

    • Urodynamic and electrophysiological methods were used to evaluate 60 diabetes mellitus subjects.
    • Subjects included those with suggestive symptoms, newly diagnosed, and treated diabetics.
    • Neuropathic bladder dysfunction was objectively identified in 71.7% of participants.

    Findings:

    • The most common bladder abnormality was a hypotonic, insensitive, large-capacity bladder, often asymptomatic.

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  • 15% experienced bladder decompensation with sphincter issues, leading to urinary retention and infection.
  • 100% showed sensory deficits in lower limbs; 69% had associated motor abnormalities, more pronounced in lower limbs.

    • Implications:

    • Subclinical diabetic neuropathy is highly prevalent, affecting both peripheral nerves and bladder function.
    • Neuropathy's severity correlates with diabetes severity, not necessarily duration.
    • These findings underscore the need for greater clinical emphasis on diabetic uropathy and neuropathy screening.