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Related Experiment Videos

Characterization of a hyperactive segment at the rectosigmoid junction

A R Chowdhury, V P Dinoso, S H Lorber

    Gastroenterology
    |October 1, 1976
    PubMed
    Summary

    Constipated individuals often exhibit a hyperactive segment at the rectosigmoid junction, characterized by continuous complex wave activity. This overactivity, responsive to atropine and glucagon, suggests muscarinic effector cell involvement in constipation.

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    Area of Science:

    • Gastroenterology
    • Colorectal Physiology
    • Digestive System Motility

    Background:

    • The rectosigmoid junction plays a crucial role in colonic and rectal motor patterns.
    • Understanding motor disorders in constipation is essential for effective treatment.

    Purpose of the Study:

    • To investigate the frequency and characteristics of a hyperactive segment at the rectosigmoid junction in constipated subjects.
    • To determine the influence of certain hormones and drugs on this hyperactive segment.

    Main Methods:

    • Studied intraluminal motor patterns of the colon and rectum in 36 subjects with colonic motor disorders and 12 healthy controls.
    • Administered secretin, cholecystokinin, atropine, and glucagon to assess their effects on wave activity.
    • Quantified wave activity and motility index of the rectosigmoid junction.

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    Main Results:

    • A persistent hyperactive segment at the rectosigmoid junction was observed in 75% of constipated patients.
    • This hyperactive segment was largely unaffected by secretin and cholecystokinin.
    • Atropine and glucagon significantly inhibited wave activity and decreased the motility index, indicating muscarinic effector cell overactivity.

    Conclusions:

    • A segmental area of overactivity at the rectosigmoid junction is present in most constipated subjects.
    • This overactivity is likely mediated by muscarinic effector cells.
    • The findings suggest a potential target for therapeutic interventions in constipation.