Alpha 1-antichymotrypsin mutations in patients with chronic obstructive pulmonary disease
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Updated: Oct 30, 2026

Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure
Published on: August 25, 2017
A J Sandford1, T Chagani, T D Weir
1Respiratory Health Network of Centres of Excellence, University of British Columbia Pulmonary, Vancouver, Canada. asandford@prl.pulmonary.ubc.ca
Abstract:
Mutations in the alpha 1-antichymotrypsin gene have been described which result in reduced levels of alpha 1-antichymotrypsin in the serum. Previous studies have suggested that two of these mutations (Pro227-->Ala and Leu55-->Pro) predispose to chronic obstructive pulmonary disease (COPD). We have investigated the prevalence of these mutations in 168 COPD patients and 61 controls without airflow obstruction. The prevalence of the Pro227-->Ala mutation was 0.9% and it was not associated with impaired lung function. None of the subjects had the Leu55-->Pro mutation.
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