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PCPP as a parenteral adjuvant for diverse antigens
L G Payne1, G Van Nest, G L Barchfeld
1Virus Research Institute, Inc., Cambridge, MA, USA.
Developments in Biological Standardization
|April 29, 1998
Summary
The phosphazene polymer, poly[di(carboxylatophenoxy) phosphazene] (PCPP), is a potent adjuvant for various vaccines. PCPP demonstrates general utility and superior performance compared to other polyanions.
Area of Science:
- Immunology
- Polymer Science
Background:
- Adjuvants enhance immune responses to vaccines.
- Novel adjuvants are needed for improved vaccine efficacy.
Purpose of the Study:
- To evaluate the adjuvanticity of poly[di(carboxylatophenoxy) phosphazene] (PCPP).
- To assess PCPP's efficacy with diverse immunogens.
Main Methods:
- Testing PCPP with trivalent influenza virus vaccine, tetanus toxoid (TT), hepatitis B surface antigen, herpes simplex virus glycoprotein gD2, and polyribosylribitolphosphate from Haemophilus influenzae type b.
- Comparing PCPP's adjuvant activity to polymethylacrylic acid and polyacrylic acid.
Main Results:
- PCPP demonstrated potent adjuvanticity across all tested immunogens.
- PCPP proved to be a superior adjuvant compared to other negatively charged polyanions, particularly with TT.
Conclusions:
- PCPP exhibits general utility as a potent adjuvant.
- PCPP represents a promising adjuvant candidate for various vaccine applications.