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Antidepressant-induced sexual dysfunction

R T Segraves1

  • 1Department of Psychiatry, Case Western Reserve University School of Medicine, and MetroHealth Medical Center, Cleveland, Ohio 44109-1998, USA.

The Journal of Clinical Psychiatry
|April 29, 1998
PubMed
Summary
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Antidepressant medications, particularly serotonin selective reuptake inhibitors (SSRIs), can cause sexual side effects like decreased libido and orgasm issues. Treatment adjustments can often restore sexual function while maintaining antidepressant efficacy.

Area of Science:

  • Pharmacology
  • Sexual Medicine
  • Psychiatry

Background:

  • Sexual side effects are a significant concern with antidepressant use.
  • Serotonin selective reuptake inhibitors (SSRIs) are commonly associated with these adverse events.
  • Patient quality of life can be impacted by antidepressant-induced sexual dysfunction.

Purpose of the Study:

  • To review current evidence on sexual side effects of antidepressant drugs.
  • To highlight the prevalence and nature of these side effects.
  • To discuss available management strategies for antidepressant-induced sexual dysfunction.

Main Methods:

  • Review of controlled studies and existing literature.
  • Analysis of reported sexual side effects associated with various antidepressant classes.

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  • Examination of treatment options for managing sexual dysfunction.

    • Main Results:

    • Controlled studies confirm that some antidepressants adversely affect libido and orgasm.
    • Orgasmic dysfunction and ejaculatory delay are common SSRI-induced sexual side effects.
    • Bupropion and nefazodone exhibit a low incidence of sexual side effects.

    Conclusions:

    • Clinicians must inquire about sexual function when prescribing SSRIs due to frequent side effects.
    • Pharmacologic regimen modification is often effective in restoring sexual function.
    • Effective treatment options exist for managing antidepressant-induced sexual dysfunction.