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Bupropion sustained release and smoking cessation

M G Goldstein1

  • 1Miriam Hospital and Department of Psychiatry and Human Behavior, Brown University School of Medicine, Providence, RI 02906, USA.

The Journal of Clinical Psychiatry
|April 29, 1998
PubMed
Summary

Bupropion sustained release (SR) is now FDA-approved for smoking cessation. This medication offers a new option for healthcare providers to help patients quit smoking by addressing nicotine dependence.

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Area of Science:

  • Pharmacology
  • Psychiatry
  • Addiction Medicine

Background:

  • Nicotine dependence is recognized as a psychiatric disorder.
  • Advances in understanding nicotine's neuropharmacology drive the search for new cessation aids.
  • Existing treatments for smoking cessation are continually being evaluated for efficacy and safety.

Purpose of the Study:

  • To review the efficacy and safety of bupropion sustained release (SR) for smoking cessation.
  • To provide an overview of nicotine's pharmacologic effects and the development of nicotine dependence.
  • To discuss general principles and strategies for treating nicotine dependence.

Main Methods:

  • Literature review of bupropion SR for smoking cessation.
  • Analysis of nicotine's neuropharmacologic effects and dependence mechanisms.
  • Examination of clinical evidence supporting bupropion SR's efficacy.

Main Results:

  • Bupropion SR has demonstrated efficacy and safety for smoking cessation.
  • The Food and Drug Administration (FDA) has approved bupropion SR for this indication.
  • This approval expands treatment options for clinicians and patients.

Conclusions:

  • Bupropion SR represents a significant advancement in pharmacologic interventions for smoking cessation.
  • Understanding nicotine dependence is crucial for developing effective treatment strategies.
  • The availability of bupropion SR enhances opportunities for addressing smoking cessation in clinical practice.

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