Related Experiment Video
Updated: Aug 16, 2026
Mouse Bladder Wall Injection
Published on: July 12, 2011
Delayed hypersensitivity and systemic arthralgia following transurethral collagen injection for stress urinary
1Department of Surgery, University of British Columbia, Vancouver, Canada.
Purpose:
During a prospective cohort study to determine the effectiveness of and adverse effects associated with transurethral collagen injection for treatment of stress urinary incontinence in women, we observed 3 cases of delayed allergic reaction at the skin test site associated with arthralgia.
Materials And Methods:
A total of 337 women with at least a 1-year history, physical findings and urodynamic abnormalities consistent with stress urinary incontinence, who required pads or protective clothing and who had no or only grade 1 cystocele were enrolled in this prospective cohort study. Adverse effects were documented by a third party at each followup.
Results:
Delayed reaction at the skin test site occurred in 3 patients (0.9%), and was associated with arthralgias in 2.
Conclusions:
The incidence and systemic nature of this type of reaction suggest that gluteraldehyde cross-linked collagen injection is not as innocuous as previously believed. Patients should be counseled regarding the unknown long-term outcome of this complication. Before treatment clinicians should consider double skin testing.
More Related Videos
05:18Ultrasound-Guided Needle Release Combined with Corticosteroid Injection for the Treatment of Supinator Syndrome
Published on: May 26, 2023
03:55Urethroplasty with Pedicled Tunica Vaginalis for the Treatment of Long-segment Anterior Urethral Stricture Caused by Lichen Sclerosus of Glans Penis
Published on: October 18, 2024