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Growth hormone therapy update in Thailand

K Angsusingha1, S Watcharasindhu, S Likitmaskul

  • 1Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Hormone Research
|April 29, 1998
PubMed

Insights

Recombinant DNA human growth hormone (rhGH) therapy significantly improved height velocity in children with growth hormone deficiency (GHD) in Thailand. The treatment showed no adverse effects, indicating its safety and efficacy for pediatric GHD management.

Area of Science:

  • Pediatrics
  • Endocrinology
  • Growth Disorders

Background:

  • Growth hormone deficiency (GHD) affects numerous children globally.
  • Idiopathic isolated GHD is a common diagnosis among pediatric patients.
  • Limited access to recombinant DNA human growth hormone (rhGH) treatment in Thailand was observed.

Purpose of the Study:

  • To evaluate the efficacy and safety of rhGH therapy in Thai children with GHD.
  • To assess the impact of rhGH on height velocity and height standard deviation score (SDS).

Main Methods:

  • A cohort of 30 GHD children received rhGH treatment for 1-2 years.
  • Height velocity, bone age, and height SDS were monitored.
  • Thyroid function and glycosylated hemoglobin levels were assessed.

Main Results:

  • Statistically significant increases in height velocity were observed post-treatment (8.17+/-1.9 cm/year and 7.36+/-2.8 cm/year at 1 and 2 years, respectively) compared to pretreatment values (3.91+/-1.09 cm/year).
  • Improved height SDS was noted at the end of each treatment period.
  • No adverse effects or abnormalities in thyroid function or glycosylated hemoglobin were reported.

Conclusions:

  • rhGH therapy is effective in improving linear growth in Thai children with GHD.
  • The treatment is well-tolerated with a favorable safety profile.
  • rhGH therapy offers a viable therapeutic option for pediatric GHD in the studied population.

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