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[Urate nephrolithiasis. Cause of consequence?]

D P Mertz

    Fortschritte Der Medizin
    |July 15, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Urate stones, a common cause of kidney stones, are linked to conditions like gout and hyperuricemia. Understanding their formation and management is crucial for preventing recurrence.

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    Area of Science:

    • Nephrology
    • Urology
    • Biochemistry

    Context:

    • Post-WWII increase in urolithiasis incidence.
    • Urate calculi constitute nearly 25% of examined renal calculi.
    • Two incidence peaks observed: adolescence and ages 40-60.

    Purpose:

    • To review the etiology and risk factors for uric acid urolithiasis.
    • To discuss the association between uric acid stones and hyperuricemia.
    • To present modern prophylactic and therapeutic strategies.

    Summary:

    • Uric acid, sodium acid urate, and ammonium acid urate are key constituents of renal calculi.
    • Formation is associated with gout, primary/secondary hyperuricemia, idiopathic conditions with acidic urine, and iatrogenic hyperuricemia.
    • Hyperuricemia and hyperuricosuria are linked to over 30% of recurrent calcium oxalate stone formers, with sodium urate promoting calcium oxalate precipitation (epitaxy).

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    Impact:

    • Highlights the significant role of urate metabolism in stone formation.
    • Emphasizes the frequent asymptomatic nature of uric acid stones.
    • Provides a comprehensive overview of current management approaches, including diet, medical therapy, and surgical options.