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Related Experiment Video

Updated: Jul 15, 2026

Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus (KSHV)

Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus (KSHV)

Published on: September 15, 2010

Pseudo-Kaposi's sarcoma (Mali type)

H Kapdağli¹, K Gündüz, G Oztürk

¹Department of Dermatology, University of Ege Medical School, Izmir, Turkey.

International Journal of Dermatology

|April 29, 1998

Summary

A rare vascular anomaly caused arteriovenous shunts, leading to leg and penile lesions in an elderly man. Prompt diagnosis through angiography and histology is crucial for understanding this condition.

Area of Science:

Vascular Surgery
Dermatopathology
Medical Imaging

Background:

A 75-year-old male patient presented with a 5-year history of lesions on his right leg and penis.
The lesions appeared after long-distance travel, accompanied by leg swelling and a dark-violet, elevated mass.

Observation:

Physical examination revealed a significant lesion extending from the leg to the thigh and penis.
Histological analysis showed thickened arteriolar walls and vascular proliferation dissecting dermal collagen.
Immunohistochemistry for Factor VIII R-A was positive in arteriolar endothelium but negative in surrounding vascular spaces.

Findings:

Femoral angiography identified multiple small arteriovenous (A-V) shunts in the distal right leg.
The histopathological findings suggest an acquired arteriovenous malformation.

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Implications:

This case highlights the importance of considering vascular anomalies in patients with unusual skin lesions.
Accurate diagnosis requires a combination of clinical presentation, histology, and advanced imaging techniques like angiography.
Understanding the pathogenesis of these A-V shunts can inform future treatment strategies for similar conditions.