Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Decelerating flow ventilation effects in acute respiratory failure

A Alvarez1, M Subirana, S Benito

  • 1Intensive Care Service, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Spain.

Journal of Critical Care
|April 29, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dynamic microbiota in water kefir: microbial shift and ecological selection during fermentation.

BMC microbiology·2025
Same author

Acoustic characteristics of the voice of children with cochlear implant.

Acta otorrinolaringologica espanola·2025
Same author

Current smoking is related to severe damage in systemic lupus erythematosus patients.

Lupus·2024
Same author

Setting up regional diagnostic reference levels for pediatric interventional cardiology in Latin America and the Caribbean countries: preliminary results and identified challenges.

Journal of radiological protection : official journal of the Society for Radiological Protection·2022
Same author

RADIOPROTECTION SURVEILLANCE OF THE TJ-II OPERATION BY TLD.

Radiation protection dosimetry·2022
Same author

Study of nitrogen implantation in Ti surface using plasma immersion ion implantation & deposition technique as biocompatible substrate for artificial membranes.

Materials science & engineering. C, Materials for biological applications·2020
Same journal

Greening critical care by harnessing the planetary impact of medications: What fellows need to know.

Journal of critical care·2026
Same journal

High-dose corticosteroids are associated with higher mortality in patients with COVID-19 ARDS: Results from a nationwide observational study.

Journal of critical care·2026
Same journal

Community-acquired pneumonia outcome is strongly influenced by early arterial pH.

Journal of critical care·2026
Same journal

Measuring attitudes toward death and dying among adult intensive care unit staff: A systematic review of assessment tools.

Journal of critical care·2026
Same journal

Identifying subgroups of ICU patients with high mortality rates using machine learning: A nationwide, population-based study.

Journal of critical care·2026
Same journal

Balanced crystalloids versus saline and mortality in hospitalized patients: a hierarchical Bayesian meta-analysis of cluster-randomized trials.

Journal of critical care·2026
See all related articles

Pressure-regulated volume-controlled ventilation (PRVC) and pressure-controlled ventilation (PC) lower peak inspiratory pressure and PaCO2 in acute respiratory failure patients compared to volume-controlled ventilation (VC). Further research is needed to establish clinical relevance.

Area of Science:

  • Critical Care Medicine
  • Respiratory Physiology
  • Mechanical Ventilation

Background:

  • Acute respiratory failure necessitates mechanical ventilation to support gas exchange.
  • Optimizing ventilator settings is crucial to minimize lung injury and improve patient outcomes.
  • Pressure-limited ventilation modes offer potential advantages over traditional volume-controlled ventilation.

Purpose of the Study:

  • To compare the effects of pressure-controlled ventilation (PC) and pressure-regulated volume-controlled ventilation (PRVC) on lung mechanics and gas exchange.
  • To evaluate these effects against baseline volume-controlled ventilation (VC) in patients with acute respiratory failure.

Main Methods:

  • A randomized crossover study involving 10 patients with acute respiratory failure.

Related Experiment Videos

  • Patients were ventilated with PC and PRVC modes for 1 hour each, with VC as a baseline.
  • Respiratory mechanics, gasometrics, and hemodynamic parameters were measured at set intervals.

    • Main Results:

    • No significant differences were observed between the three volume-controlled ventilation (VC) periods.
    • Both PC and PRVC modes resulted in a significant decrease in peak inspiratory pressure compared to VC.
    • PaCO2 levels were significantly reduced with PC and PRVC compared to VC.

    Conclusions:

    • Pressure-limited ventilation modes (PC and PRVC) can achieve similar tidal volumes as VC with lower peak inspiratory pressures.
    • A slight reduction in PaCO2 was observed with pressure-limited modes, potentially due to improved air distribution.
    • The clinical significance of these findings requires further investigation.