Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Phorbol esters: useful tools to study megakaryocyte differentiation

S Baatout1

  • 1Laboratory of Experimental Hematology and Oncology, UCL, Brussels, Belgium.

Hematology and Cell Therapy
|April 29, 1998
PubMed
Summary

Phorbol esters impact megakaryocyte cell lines, offering insights into megakaryocytopoiesis. These cell lines serve as a valuable model for understanding megakaryocyte maturation mechanisms.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Joint research towards a better radiation protection-highlights of the Fifth MELODI Workshop.

Journal of radiological protection : official journal of the Society for Radiological Protection·2014
Same author

520-d Isolation and confinement simulating a flight to Mars reveals heightened immune responses and alterations of leukocyte phenotype.

Brain, behavior, and immunity·2014
Same author

Biological carrier molecules of radiopharmaceuticals for molecular cancer imaging and targeted cancer therapy.

Current pharmaceutical design·2014
Same author

Transgenerational developmental effects and genomic instability after X-irradiation of preimplantation embryos: studies on two mouse strains.

Mutation research·2010
Same author

Controlled light exposure microscopy reveals dynamic telomere microterritories throughout the cell cycle.

Cytometry. Part A : the journal of the International Society for Analytical Cytology·2008
Same author

Genrisk-T project: response of the TPC-1 papillary thyroid carcinoma cell line to a range of low to high doses of irradiation.

Communications in agricultural and applied biological sciences·2008

Area of Science:

  • Hematology
  • Cell Biology
  • Molecular Biology

Background:

  • Megakaryocyte maturation is crucial for platelet production.
  • Understanding the regulation of megakaryocytopoiesis is essential for treating bleeding disorders.

Purpose of the Study:

  • To review recent findings on phorbol ester effects on megakaryocyte cell lines.
  • To correlate in vitro observations with in vivo megakaryocytopoiesis.
  • To establish phorbol ester-stimulated megakaryocyte cell lines as a model for studying maturation.

Main Methods:

  • Literature review of studies on phorbol esters and megakaryocyte cell lines.
  • Analysis of in vivo data on megakaryocytopoiesis.
  • Evaluation of the utility of cell line models.

Main Results:

  • Phorbol esters induce specific changes in megakaryocyte cell lines.
  • These changes reflect aspects of in vivo megakaryocyte development.
  • Stimulated cell lines offer a tractable system for mechanistic studies.

Conclusions:

  • Phorbol ester-treated megakaryocyte cell lines are a relevant model for studying maturation.
  • This model aids in elucidating the molecular mechanisms of megakaryocytopoiesis.
  • Further research using this model can advance understanding of platelet formation.

Related Experiment Videos