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Related Experiment Videos

Iodide supplementation: 200 micrograms daily or 1,500 micrograms weekly?

R Wahl1, M Breidt, E Kallee

  • 1Medizinische Klinik und Poliklinik, Abt. IV Eberhard-Karls-Universität Tübingen.

Zeitschrift Fur Ernahrungswissenschaft
|April 29, 1998
PubMed
Summary

This study compared daily versus weekly iodine supplementation in euthyroid volunteers. Both diiodotyrosine and iodide administration showed similar iodine excretion rates after eight weeks, indicating comparable bioavailability.

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Area of Science:

  • Endocrinology
  • Nutritional Science
  • Pharmacokinetics

Background:

  • Iodine is essential for thyroid hormone synthesis.
  • Understanding iodine bioavailability from different supplement forms is crucial for effective nutritional strategies.
  • Daily versus weekly dosing regimens may impact iodine absorption and utilization.

Purpose of the Study:

  • To compare the bioavailability of iodine administered daily as diiodotyrosine versus weekly as iodide.
  • To assess iodine excretion patterns in euthyroid individuals under different supplementation schedules.

Main Methods:

  • Twenty-five euthyroid volunteers were divided into two groups.
  • Group A received 200 micrograms of iodine daily as diiodotyrosine for eight weeks.
  • Group B received 1,500 micrograms of iodine weekly as iodide for eight weeks.

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  • Urinary iodine excretion was measured to determine bioavailability.

    • Main Results:

    • Urinary iodine excretion in Group A reached 67% of the applied dose by the eighth week.
    • Urinary iodine excretion in Group B reached 65% of the applied dose by the eighth week.
    • No significant difference in iodine excretion was observed between the two groups.

    Conclusions:

    • Daily supplementation with diiodotyrosine and weekly supplementation with iodide demonstrate similar iodine bioavailability in euthyroid individuals.
    • The frequency of iodine supplementation does not appear to significantly alter its excretion rate over an eight-week period.
    • These findings suggest flexibility in designing iodine supplementation regimens based on patient adherence and convenience.