Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Bioavailability of 17 beta-estradiol after transdermal administration--dependence on the patch system]

J Schmolling1, J Kusche, H van der Ven

  • 1Universitäts-Frauenklinik Bonn.

Zentralblatt Fur Gynakologie
|April 29, 1998
PubMed
Summary

This study compared two transdermal estradiol systems in postmenopausal women. The matrix system provided higher mean serum estradiol concentrations over 80 hours compared to the reservoir system.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ninety-five orthotopic transplantations in 74 women of ovarian tissue after cytotoxic treatment in a fertility preservation network: tissue activity, pregnancy and delivery rates.

Human reproduction (Oxford, England)·2016
Same author

Live birth after artificial oocyte activation using a ready-to-use ionophore: a prospective multicentre study.

Reproductive biomedicine online·2015
Same author

Cryopreservation of Ovarian Tissue: Detailed Description of Methods for Transport, Freezing and Thawing.

Geburtshilfe und Frauenheilkunde·2014
Same author

Efficacy of ovarian tissue cryopreservation in a major European center.

Journal of assisted reproduction and genetics·2014
Same author

In vitro and in vivo degradation profile of aliphatic polyesters subjected to electron beam sterilization.

Acta biomaterialia·2011
Same author

Altered first-trimester screening markers after IVF/ICSI: no relationship with small-for-gestational-age and number of embryos transferred.

Reproductive biomedicine online·2010

Area of Science:

  • Endocrinology
  • Pharmacology
  • Gynecology

Background:

  • Postmenopausal hormone therapy aims to alleviate symptoms by restoring hormone levels.
  • Transdermal estradiol delivery systems offer an alternative to oral administration, potentially with improved safety profiles.
  • Comparing different delivery systems is crucial for optimizing therapeutic outcomes.

Purpose of the Study:

  • To compare the pharmacokinetics of serum estradiol concentrations between two transdermal estradiol delivery systems.
  • To evaluate estradiol absorption and serum levels over an 80-hour period.
  • To assess the suitability of each system for postmenopausal hormone substitution.

Main Methods:

  • Prospective randomized crossover study in ten postmenopausal women.

Related Experiment Videos

  • Application of two transdermal estradiol patches: a reservoir system (4.0 mg E2) and a matrix system (1.8 mg E2).
  • Measurement of serum estradiol concentrations over 80 hours with a 7-day washout period.

    • Main Results:

    • The matrix system resulted in significantly higher mean serum estradiol concentrations over 80 hours (p < 0.05).
    • Estradiol levels were notably higher with the matrix system at the end of the observation period and after patch removal.
    • While fluctuations were greater with the matrix system, areas under the curve were not significantly different.

    Conclusions:

    • Both transdermal estradiol systems are suitable for postmenopausal hormone substitution, achieving stable serum estradiol levels around 50 pg/ml.
    • The matrix system may offer an extended lifespan, potentially allowing for longer application periods.
    • Further research could explore the clinical implications of the observed pharmacokinetic differences.