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Epidemiology of lymphomas in children residing in Mexico City
H F Mendoza-Sánchez1, J A Quintana-Sánchez, H Rivera-Márquez
1Unidad de Investigación Médica en Epidemiología Clínica, Instituto Mexicano del Seguro Social, México, D.F., México.
Insights
Childhood lymphomas in Mexico City show distinct epidemiological patterns for Hodgkin's disease (HD) and non-Hodgkin's lymphomas (NonHL). These patterns, varying by age, sex, and residence, align with broader Latin American trends.
Area of Science:
- Pediatric Oncology
- Epidemiology
- Hematology
Background:
- Lymphomas represent a significant group of childhood cancers.
- Understanding the epidemiological characteristics of pediatric lymphomas is crucial for public health strategies.
- Mexico City (MC) presents a unique demographic for studying these characteristics.
Purpose of the Study:
- To delineate the epidemiological features of childhood lymphomas in Mexico City.
- To analyze variations in lymphoma incidence based on time, subject (age, sex), and place of residence.
- To compare the epidemiological profiles of Hodgkin's disease (HD) and non-Hodgkin's lymphomas (NonHL).
Main Methods:
- A retrospective hospital survey was conducted, reviewing records of children diagnosed with lymphomas between 1982 and 1991.
- Neoplasms were classified as Hodgkin's disease (HD) or non-Hodgkin's lymphomas (NonHL).
- Incidence, trends by sex, age, area of residence, time of diagnosis, and parental socioeconomic factors were evaluated.
Main Results:
- A significant trend was observed for HD (r:0.62; P = 0.05).
- In 1991, lymphoma incidence rates per 10^6 children were 6.12 for HD and 3.87 for NonHL.
- Incidence peaked in children aged 5-9 years for HD and 1-9 years for NonHL, with higher rates in boys for both categories. Variations were noted by residence and parental factors.
Conclusions:
- The epidemiological patterns of HD and NonHL in children differ significantly.
- Both lymphoma types in Mexico City exhibit epidemiological characteristics consistent with those observed in Latin American populations.
- These findings underscore the importance of region-specific epidemiological surveillance for childhood lymphomas.
Background:
The aim of this paper is to present the epidemiological characteristics of time, subject and place of lymphomas in children residing in Mexico City, Mexico (MC).
Methods:
The type of study was a retrospective hospital survey. All records of children with lymphomas registered between 1982 and 1991 at the main hospitals that treat children with cancer in MC were reviewed. Neoplasms were classified into Hodgkin's disease (HD) and non-Hodgkin's lymphomas (NonHL). Trend and incidence by sex, age and area of residence in MC were evaluated. Time of diagnosis, as well as parental occupation and educational level, were registered.
Results:
A trend was only observed for HD in the total group (r:0.62; P = 0.05). In 1991, incidence for HD was 6.12 (rates x 10(6)) and 3.87 for NonHL. The highest average incidence was found in children 5-9 years of age (5.40) for HD, and in the age groups of 1-4 and 5-9 (3.10 and 3.33, respectively), for NonHL. Incidence was higher among boys for both lymphoma categories, but the male-to-female ratio was much higher in HD. Time of diagnosis, incidence in terms of place of residence, and parental educational level and occupation also differed from one lymphoma category to the other.
Conclusion:
The epidemiology of HD is different from that of NonHL, both showing a pattern similar to that of Latin American children.