Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

470
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
470
Nephrotic Syndrome II : Assessment and Medical Management01:26

Nephrotic Syndrome II : Assessment and Medical Management

189
IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
189
Myocarditis III: Medical Management01:14

Myocarditis III: Medical Management

168
Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...
168
Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

249
Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
249
Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

399
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
399
Autoimmune Disorders01:29

Autoimmune Disorders

1.4K
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
1.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Skin autofluorescence is increased in systemic lupus erythematosus but is not reflected by elevated plasma levels of advanced glycation endproducts.

Rheumatology (Oxford, England)ยท2008
Same author

Accumulation of advanced glycation endproducts in patients with systemic lupus erythematosus.

Rheumatology (Oxford, England)ยท2007
Same author

Opposed independent effects and epistasis in the complex association of IRF5 to SLE.

Genes and immunityยท2007
Same author

Traditional and non-traditional risk factors contribute to the development of accelerated atherosclerosis in patients with systemic lupus erythematosus.

Lupusยท2006
Same author

Accelerated atherosclerosis in patients with Wegener's granulomatosis.

Annals of the rheumatic diseasesยท2004
Same author

The role of myeloperoxidase in the pathogenesis of systemic vasculitis.

Clinical and experimental rheumatologyยท2004

Related Experiment Video

Updated: Jan 12, 2026

Murine Bilateral Renal Lymphadenectomy
06:20

Murine Bilateral Renal Lymphadenectomy

Published on: December 30, 2025

10

[Immunology in clinical practice IX. Systemic vasculitis]

C G Kallenberg1, J W Tervaert

  • 1Academisch Ziekenhuis, afd. Inwendige Geneeskunde, Groningen.

Nederlands Tijdschrift Voor Geneeskunde
|April 29, 1998
PubMed
Summary
This summary is machine-generated.

Diagnosing vasculitis requires histopathological proof due to look-alike conditions. Antineutrophil cytoplasmic antibodies aid diagnosis, with treatments including corticosteroids and immunosuppression.

More Related Videos

Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model
07:40

Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model

Published on: January 12, 2022

6.0K
Supervised Machine Learning for Semi-Quantification of Extracellular DNA in Glomerulonephritis
09:16

Supervised Machine Learning for Semi-Quantification of Extracellular DNA in Glomerulonephritis

Published on: June 18, 2020

7.3K

Related Experiment Videos

Last Updated: Jan 12, 2026

Murine Bilateral Renal Lymphadenectomy
06:20

Murine Bilateral Renal Lymphadenectomy

Published on: December 30, 2025

10
Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model
07:40

Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model

Published on: January 12, 2022

6.0K
Supervised Machine Learning for Semi-Quantification of Extracellular DNA in Glomerulonephritis
09:16

Supervised Machine Learning for Semi-Quantification of Extracellular DNA in Glomerulonephritis

Published on: June 18, 2020

7.3K

Area of Science:

  • Rheumatology and Immunology
  • Pathology

Background:

  • Vasculitis diagnosis often necessitates histopathological confirmation to differentiate from mimics.
  • Vasculitis encompasses primary (idiopathic) and secondary forms, frequently linked to infections.

Observation:

  • Primary vasculitides classification depends on vessel size, inflammation type, and clinical presentation.
  • Autoantibodies, specifically antineutrophil cytoplasmic antibodies (ANCA), are crucial in diagnosing certain primary vasculitides.
  • ANCA detection offers insights into the pathophysiology of primary vasculitides.

Findings:

  • Histopathological evidence is key for accurate vasculitis diagnosis.
  • Antineutrophil cytoplasmic antibodies (ANCA) improve diagnostic capabilities for primary vasculitides.
  • Current treatments involve corticosteroids and immunosuppression.

Implications:

  • Understanding vasculitis pathophysiology through autoantibodies can lead to improved diagnostics.
  • Future research may yield more targeted and less toxic therapeutic strategies for vasculitis.
  • Accurate diagnosis is critical for managing vasculitis and its look-alike conditions.