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[Risk factors for atherosclerosis in offspring of parents with primary hypertriglyceridemia]
B Torbus-Lisiecka1, M Jastrzebska, B Szafrańska
1Zakład Biochemii Klinicznej i Diagnostyki Laboratoryjnej Pomorskiej AM.
Insights
Children with a family history of high triglycerides have lower HDL cholesterol and higher blood pressure. Parental lipid and hemostasis factors significantly influence children's triglyceride levels and clot lysis time.
Area of Science:
- Cardiovascular Health
- Pediatric Endocrinology
- Lipid Metabolism
Background:
- High triglycerides and reduced fibrinolysis are key atherosclerosis predictors.
- Family history of hypertriglyceridemia (HTG) may indicate inherited risk factors.
- Early identification of pediatric risk factors is crucial for cardiovascular disease prevention.
Purpose of the Study:
- Compare triglyceride and fibrinolysis levels in children with and without a family history of HTG.
- Assess the association between offspring and parental risk factors for atherosclerosis.
- Investigate the influence of parental lipid and hemostasis parameters on children's cardiovascular risk markers.
Main Methods:
- Study included children (7-12 years) with HTG family history and healthy controls (5-12 years).
- Measured plasma levels of triglycerides, cholesterol, apolipoproteins, and fibrinogen.
- Assessed plasminogen activator inhibitor-1 (PAI-1), fibrinolysis activity, and euglobulin lysis time (ELT).
Main Results:
- Children with HTG family history showed lower HDL-cholesterol and HDL2-cholesterol levels.
- Higher prevalence of elevated blood pressure and ECG disturbances observed in the HTG family history group.
- Multiple regression analysis revealed strong determination of children's triglycerides and ELT by parental lipid and hemostasis parameters in the HTG group.
Conclusions:
- A positive family history of HTG is associated with adverse lipid profiles and clinical findings in children.
- Parental lipid and hemostasis profiles significantly predict triglyceride levels and fibrinolytic activity in offspring.
- Early screening and intervention in children with a family history of HTG are warranted to mitigate atherosclerosis risk.
Abstract:
High triglycerides and low fibrinolysis activity are considered as a significant predictors for atherosclerosis. The aim of our study was: 1-to compare these risk factors levels in children with positive family history of hypertriglyceridemia (HTG) with children from healthy families and 2-to assess the association between triglyceride and fibrinolysis activity in offspring (y) and parental risk factors (xl ... xn) for atherosclerosis. The study population consisted of: I Group 15 children 7-12 years old and their parents from HTG families and II Group 26 control children 5-12 years old from healthy families. Triglyceride (TG), total cholesterol, cholesterol esters, LDL-Ch, HDL-Ch, HDL2Ch, apolipoprotein AI and BII, fibrinogen plasma level were determined. Plasminogen activator inhibitor (PAI-1) and fibrinolysis activity and (ELT) were determined. We found significant differences in clinical examinations (higher blood pressure and ECG disturbances more frequently), HDL-Ch and HDL2-Ch plasma level was lower in children with positive family history than in control children. Multiple regression analysis of parental variables demonstrated, that children's TG and ELT are strongly determined by parental lipids and haemostasis parameters in children with positive family history of HTG.