Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

IL-10 production in common variable immunodeficiency

Z Zhou1, R Huang, M Danon

  • 1Division of Clinical Immunology, Mt. Sinai Medical Center, New York, New York 10029, USA.

Clinical Immunology and Immunopathology
|April 29, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Is there an independant anti-suicidal effect of esketamine in treatment resistant depression?

Journal of affective disorders·2026
Same author

Improved decision-making in patients with mood disorders following Transcranial Direct Current Stimulation (tDCS) applied to the left orbitofrontal cortex: A proof-of-concept study.

Journal of affective disorders·2025
Same author

Immunogenicities of vaccines including the immunoglobulin M-degrading enzyme of <i>Streptococcus suis</i>, rIde <sub></sub> , and protective efficacy against serotype 14 in piglets.

Vaccine: X·2024
Same author

Effect of 5 weeks of oral acetazolamide on patients with pulmonary vascular disease: A randomized, double-blind, cross-over trial.

Pulmonology·2023
Same author

Three clinical indicators of borderline personality disorder in anorexia nervosa: A pilot study.

L'Encephale·2022
Same author

TEMPus VoLA: The timed Epstein multi-pressure vessel at low accelerations.

The Review of scientific instruments·2022
Same journal

Mechanisms of virus replication, persistence, and regulation of immune responses.

Clinical immunology and immunopathology·2020
Same journal

Cumulative subject index for volumes 86-89

Clinical immunology and immunopathology·1998
Same journal

D-penicillamine-induced pancreatic islet autoantibody production is independent of the immunogenetic background: a lesson from patients with Wilson's disease.

Clinical immunology and immunopathology·1998
Same journal

Characterization of gastric Na+/I- symporter of the rat.

Clinical immunology and immunopathology·1998
Same journal

CD8(+), radiosensitive T cells of parental origin, oppose cells capable of down-regulating cytotoxicity in murine acute lethal graft-versus-host disease.

Clinical immunology and immunopathology·1998
Same journal

Specific activity of alpha1proteinase inhibitor and alpha2macroglobulin in human serum: application to insulin-dependent diabetes mellitus.

Clinical immunology and immunopathology·1998
See all related articles

Common variable immunodeficiency (CVI) involves T and B cell defects. Studies show CVI T cells have deficient IL-10 production, while monocytes produce more, impacting cell proliferation.

Area of Science:

  • Immunology
  • Cell Biology

Background:

  • Common variable immunodeficiency (CVI) is a primary immunodeficiency characterized by T and B cell defects.
  • Interleukin-10 (IL-10) and anti-CD40 signaling are known to promote immunoglobulin secretion by CVI B cells.

Purpose of the Study:

  • To investigate IL-10 production in patients with CVI.
  • To understand the role of IL-10 in T cell and B cell dysfunction in CVI.

Main Methods:

  • Assessed IL-10 production by CVI peripheral blood mononuclear cells (PBMCs) and isolated T cells following mitogen or anti-CD3 stimulation.
  • Measured IL-10 production by CVI monocytes.
  • Evaluated the effect of anti-IL-10-neutralizing antibody and IL-2 on CVI T cell proliferation responses to PHA and soluble antigens.

Related Experiment Videos

Main Results:

  • CVI T cells produced insignificant amounts of IL-10.
  • CVI monocytes exhibited substantial IL-10 production, exceeding that of normal controls.
  • Anti-IL-10 antibody enhanced CVI T cell proliferation to PHA and, more significantly, to antigens when combined with IL-2, compared to normal controls.

Conclusions:

  • CVI T cell secretion of IL-10 is deficient.
  • Increased monocyte-derived IL-10 and potentially reduced IL-2 production may contribute to impaired cell proliferation in CVI.