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Bacterial resistance in acne

E A Eady1

  • 1Department of Microbiology, University of Leeds, UK. miceae@leeds.ac.uk

Dermatology (Basel, Switzerland)
|April 29, 1998
PubMed
Summary

Antibiotic resistance in acne therapy is a growing concern, with resistant bacteria spreading from patients to close contacts. Prudent antibiotic use policies are recommended to prevent further resistance development in Propionibacterium acnes.

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Area of Science:

  • Dermatology
  • Microbiology
  • Infectious Diseases

Background:

  • Antibiotics are commonly prescribed for acne, but treatment decisions often overlook bacterial resistance.
  • Increasing duration of antibiotic therapy correlates with higher prevalence and density of resistant coagulase-negative staphylococci.
  • Acne patients serve as significant reservoirs for antibiotic-resistant nosocomial pathogens, posing transmission risks to close contacts.

Purpose of the Study:

  • To investigate antibiotic resistance in cutaneous propionibacteria, particularly Propionibacterium acnes, in acne patients.
  • To assess the prevalence and dissemination of antibiotic-resistant strains within acne patient populations and their close contacts.
  • To identify factors contributing to antibiotic resistance development and patients at higher risk.

Main Methods:

  • Review of existing literature on antibiotic resistance in acne therapy.
  • Analysis of prevalence data for resistant strains in skin flora of acne patients and their contacts.
  • Exploration of factors influencing resistance development in Propionibacterium acnes.

Main Results:

  • Antibiotic resistance, especially to erythromycin, has been reported in Propionibacterium acnes isolates globally.
  • Carriage of resistant strains can lead to therapeutic failures in some antibiotic regimens for acne.
  • In the study region, 60% of acne patients and 50% of their close contacts carried resistant strains, indicating widespread dissemination.

Conclusions:

  • Antibiotic resistance in Propionibacterium acnes is a significant issue in acne management.
  • Understanding factors driving resistance is crucial for developing targeted prevention strategies.
  • Implementation of antibiotic usage policies and improved prescribing habits are recommended to mitigate resistance emergence.

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