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Updated: Aug 10, 2026

Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas
Published on: February 28, 2019
[A rare type of neoplasia. Report of 2 cases]
L Sebastián Montal1, J L Batalla Cadira
1Servicio de Urología, Hospital Sagrado Corazón, Barcelona, España.
Objective:
To report two additional cases of carcinosarcoma of the bladder and review the literature.
Methods/Results:
Two cases of bladder tumor are described. Both patients were male whose median age at diagnosis was 69.5 years. They had consulted for post-void hypogastric pain and hematuria. A diagnosis of bladder tumor was made on the basis of the radiological and ultrasound findings and a partial cystectomy was performed. Histological examination with immunohistochemical techniques revealed carcinosarcoma of the bladder.
Conclusions:
Carcinosarcoma is a mixed tumor with a high grade of malignancy and is rarely located in the bladder. Its clinical presentation is not unlike that of other bladder tumors. Diagnosis is always by histology using immunological techniques. It has a very poor prognosis. Because it is a rare tumor type, its natural history is unknown and treatment remains unclear, although radical surgery continues to be the most widely utilized.
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