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Human olfactory mucosa in schizophrenia

G Smutzer1, V M Lee, J Q Trojanowski

  • 1Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia 19104, USA.

The Annals of Otology, Rhinology, and Laryngology
|April 29, 1998
PubMed
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Schizophrenia patients show olfactory deficits, but their olfactory epithelium molecular phenotype appears normal. Dystrophic neurites, common in both schizophrenic and control subjects, suggest olfactory dysfunction may stem from central nervous system abnormalities.

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Psychiatry

Background:

  • Schizophrenia is associated with olfactory deficits.
  • Developmental anomalies may contribute to schizophrenia symptoms.

Purpose of the Study:

  • To investigate the molecular phenotype of olfactory mucosa in elderly schizophrenic patients.
  • To identify potential molecular differences in olfactory epithelium related to schizophrenia.

Main Methods:

  • Immunohistochemistry was used to examine the distribution of various proteins in postmortem olfactory mucosa.
  • Proteins analyzed included cytoskeletal proteins, synaptic vesicle proteins, neural markers, and axonal guidance proteins.

Main Results:

  • Dystrophic neurites immunoreactive for synaptophysin, MAP1B, and neurofilament proteins were observed in both schizophrenic and control subjects.

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  • No significant differences in the expression or distribution of examined proteins were found in the olfactory epithelium between groups.

    • Conclusions:

    • The olfactory epithelium in schizophrenic patients does not show major molecular abnormalities.
    • Olfactory deficits in schizophrenia may originate from subtle cellular differences or abnormalities in central olfactory regions.