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Mouse cell surface antigens: nomenclature and immunophenotyping

L Lai1, N Alaverdi, L Maltais

  • 1PharMingen, San Diego, CA 92121, USA.

Journal of Immunology (Baltimore, Md. : 1950)
|April 29, 1998
PubMed
Summary

This review updates mouse cell surface antigen nomenclature, covering Cluster of Differentiation (CD) and Lymphocyte Antigen (Ly) series. It discusses antigen functions and utility for immunophenotyping mouse cell subsets in immunology research.

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Area of Science:

  • Immunology
  • Cell Biology
  • Biochemistry

Background:

  • Cell surface antigens (Ags) are crucial for cell identification and function.
  • Accurate nomenclature is essential for reproducible research in mouse immunology.
  • Existing mouse Ag databases require regular updates to reflect new discoveries.

Purpose of the Study:

  • To provide an updated review of mouse cell surface Ags.
  • To consolidate information on Cluster of Differentiation (CD) and Lymphocyte Antigen (Ly) series.
  • To highlight novel Ags and their potential applications in mouse immunology.

Main Methods:

  • Comprehensive literature review of mouse cell surface Ags.
  • Analysis of nomenclature updates for CD and Ly series.

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  • Compilation of information on Ag functions and immunophenotyping applications.

    • Main Results:

    • Detailed overview of mouse CD Ags (CD1-CD166) and Ly Ags (Ly-1-Ly-81).
    • Inclusion of newly identified Ags lacking current CD or Ly assignments.
    • Discussion of known Ag functions and their relevance to cell subsets.

    Conclusions:

    • The updated nomenclature facilitates clearer communication in mouse immunology.
    • Understanding Ag functions aids in dissecting cellular processes.
    • Novel markers presented offer new tools for immunophenotyping and research.