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Refractory hyperglycemia complicating an evolving connective tissue disease: response to cyclosporine
N Kramer1, E D Rosenstein, G Schneider
1Arthritis and Rheumatic Disease Center, Department of Medicine, St. Barnabas Medical Center, Livingston, NJ 07039, USA.
The Journal of Rheumatology
|April 29, 1998
Abstract:
A 33-year-old woman with longstanding rheumatoid arthritis and Sjögren's syndrome developed type B insulin resistance (diabetes mellitus due to anti-insulin receptor antibodies) simultaneous with the evolution of her rheumatic disease to mixed connective tissue disease. Cyclosporine therapy induced a remission of receptor antibody mediated insulin resistance and controlled clinical manifestations of her systemic lupus erythematosus and dermatomyositis, but had no effect on the sclerodermatous features of her illness.