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  1. Home
  3. Bone Mineral Density Assessment In Children With Inflammatory Bowel Disease
  1. Home
  3. Bone Mineral Density Assessment In Children With Inflammatory Bowel Disease

Related Experiment Video

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Bone mineral density assessment in children with inflammatory bowel disease

R Gokhale1, M J Favus, T Karrison

  • 1Section of Pediatric Gastroenterology, University of Chicago, Chicago, Illinois 60614, USA.

Gastroenterology
|May 30, 1998

View abstract on PubMed

Summary
This summary is machine-generated.

Children with inflammatory bowel disease (IBD) have lower bone mineral density (BMD), particularly those with Crohn's disease. Corticosteroid use significantly predicts reduced BMD in these pediatric patients.

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Area of Science:

  • Pediatric Endocrinology
  • Gastroenterology
  • Bone Metabolism

Background:

  • Children with inflammatory bowel disease (IBD) face increased osteoporosis risk due to malnutrition, delayed puberty, and corticosteroid use.
  • Assessing bone mineral density (BMD) is crucial for managing IBD in children.

Purpose of the Study:

  • To compare BMD in children with IBD versus healthy controls.
  • To evaluate the impact of nutritional, hormonal, and corticosteroid factors on BMD in pediatric IBD.

Main Methods:

  • 162 subjects (99 IBD, 63 controls) underwent anthropometric, pubertal, and bone age assessments.
  • BMD measured by dual-energy x-ray absorptiometry (DXA) at lumbar spine, femoral neck, and radius.
  • Extensive laboratory tests and cumulative corticosteroid doses were analyzed.

Main Results:

  • Children with IBD exhibited lower BMD Z scores at the lumbar spine and femoral neck compared to controls.
  • Crohn's disease patients had lower BMD than ulcerative colitis patients; low BMD persisted in girls with Crohn's disease.
  • Cumulative corticosteroid dose was a significant predictor of reduced BMD; calcium homeostasis measures showed limited correlation.

Conclusions:

  • Pediatric IBD patients, especially those with Crohn's disease and during puberty, have low BMD.
  • Corticosteroid dose is a key factor, but other elements contributing to low BMD in Crohn's disease require further investigation.