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The synaptic vesicle cycle

W J Betz¹, J K Angleson

¹Department of Physiology and Biophysics, University of Colorado Medical School, Denver 80262, USA.

Annual Review of Physiology

|April 29, 1998

Summary

Investigating the synaptic vesicle cycle reveals how vesicles fuse, release contents, and are recycled. This detailed examination provides insights into cellular transport mechanisms and their regulation.

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Area of Science:

Cell Biology
Neuroscience

Background:

The synaptic vesicle cycle is crucial for neurotransmission.
Understanding vesicle fusion, content release, and membrane retrieval is essential.

Purpose of the Study:

To detail the mechanisms of the synaptic vesicle cycle.
To elucidate the processes of vesicle fusion, content release, and membrane recycling.

Main Methods:

Electrophysiological techniques to study single fusion pore behavior.
Kinetic and ultrastructural analysis of membrane retrieval processes.

Main Results:

Fusion pore opening is followed by content release, which can be stuttering.
Granule membrane retrieval involves parallel processes with distinct kinetics and ultrastructure.
Synaptic vesicles undergo endocytosis, recycling, and re-mobilization for subsequent exocytosis.

Conclusions:

The synaptic vesicle cycle involves intricate steps of fusion, release, and recycling.
Diverse mechanisms contribute to membrane retrieval and vesicle pool reformation.

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