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Synthesis and biological activity of 11,19-bridged progestins
W Schwede1, K H Fritzemeier, W Halfbrodt
1Research Laboratories of Schering AG, Berlin, Germany. wolfgang.schwede@schering.de
Steroids
|April 29, 1998
Abstract:
A synthetic approach to 11,19-bridged progestins is described. The key step in the synthesis is a 6-endo-trig radical cyclisation. The new progestins were tested for their biological activities in vitro and in vivo and compared to those of known progestins.