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Miconazole as inflammatory agent. II: Time course of pleurisy and drug interference
S Hanada1, S H Sugawara, J A Sertié
1Department of Pharmacology, Instituto de Ciências Biomédicas, Universidade de São Paulo, Brazil.
General Pharmacology
|April 29, 1998
Abstract:
1. Miconazole-induced pleurisy was characterized by edema development and leukocyte infiltration. 2. This response was inhibited by chlorpheniramine, methysergide and steroidal and nonsteroidal anti-inflammatory drugs. 3. After miconazole injection, no mast cells were found in the pleural cavity. 4. Our results support the concept that biogenic amines released from mast cells and cyclooxygenase-derived mediators may contribute to the pathogenesis and evolution of miconazole inflammation.