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Effect of grapefruit juice on clarithromycin pharmacokinetics
K L Cheng1, A N Nafziger, C A Peloquin
1Department of Pharmacy Services, Bassett Healthcare, Cooperstown, New York 13326-1394, USA.
Antimicrobial Agents and Chemotherapy
|April 29, 1998
Abstract:
To investigate whether grapefruit juice inhibits the metabolism of clarithromycin, 12 healthy subjects were given water or grapefruit juice before and after a clarithromycin dose of 500 mg in a randomized crossover study. Administration of grapefruit juice increased the time to peak concentration of both clarithromycin (82 +/- 35 versus 148 +/- 83 min; P = 0.02) and 14-hydroxyclarithromycin (84 +/- 38 min versus 173 +/- 85; P = 0.01) but did not affect other pharmacokinetic parameters.