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In vitro activity of a new 8-methoxyquinolone, BAY 12-8039, against Chlamydia pneumoniae
1Department of Pediatrics, State University of New York, Health Science Center at Brooklyn, 11203, USA.
Antimicrobial Agents and Chemotherapy
|April 29, 1998
Abstract:
The in vitro susceptibilities of 10 strains of Chlamydia pneumoniae to a new 8-methoxyquinolone, BAY 12-8039, and to ofloxacin, doxycycline, and erythromycin were determined. The activity of BAY 12-8039 was similar to that of ofloxacin, with a MIC at which 90% of the isolates had no inclusions and a minimal chlamydicidal concentration at which 90% of the isolates had no inclusions after passage of 1.0 microg/ml, but this activity was less than those of doxycycline and erythromycin.