Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Calculating internal dose by convolution from SPECT/MR fusion images

J S Lampinen1, H K Pohjonen, S E Savolainen

  • 1Department of Physics, University of Helsinki, Finland. Juha.Lampinen@Helsinki.fi

Annals of Nuclear Medicine
|April 29, 1998
PubMed
Summary

A new computer program calculates absorbed radiation dose using convolution and SPECT/MR images. This method accurately estimates organ doses, proving practical for clinical applications in nuclear medicine.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparison of different cell-cluster models for cell-level dosimetry.

Acta oncologica (Stockholm, Sweden)·2001
Same author

Radiation spectra of 111In, 113mIn and 114mIn.

Acta oncologica (Stockholm, Sweden)·2000
Same author

Models for estimation of the (10)B concentration after BPA-fructose complex infusion in patients during epithermal neutron irradiation in BNCT.

International journal of radiation oncology, biology, physics·2000
Same author

Factors influencing patient radiation doses from barium enema examinations.

Acta radiologica (Stockholm, Sweden : 1987)·2000
Same author

Patient specific doses used to analyse the optimum dose delivery in barium enema examinations.

The British journal of radiology·2000
Same author

Cluster models in cellular level electron dose calculations.

Acta oncologica (Stockholm, Sweden)·1999

Area of Science:

  • Medical Imaging
  • Radiation Dosimetry
  • Nuclear Medicine

Background:

  • Accurate absorbed dose calculation is crucial for nuclear medicine procedures.
  • Existing methods may have limitations in precision and applicability.
  • Integration of functional imaging with anatomical data is advancing personalized medicine.

Purpose of the Study:

  • To develop and validate a novel computer program for calculating absorbed radiation dose.
  • To assess the program's accuracy using SPECT/MR fusion images and convolution methods.
  • To evaluate the clinical applicability of the developed dosimetry program.

Main Methods:

  • Development of a computer program utilizing the convolution method.
  • Application of abdominal SPECT/MR fusion images for anatomical alignment.

Related Experiment Videos

  • Validation using radiopharmaceutical studies with technetium-99m (99mTc) and indium-111 (111In).

    • Main Results:

    • The program accurately calculated absorbed doses in liver and spleen for 99mTc-labeled colloid studies, showing good agreement with Monte Carlo (MC) methods.
    • Dose estimates for 111In-labeled thrombocyte studies showed some discrepancies attributed to activity quantitation approximations.
    • Convolution of activity distribution with a point dose kernel proved effective for homogeneous media.

    Conclusions:

    • The developed computer program is effective for calculating absorbed dose distributions.
    • The method is practical for clinical use in nuclear medicine when input data are available.
    • Accurate activity quantitation is essential for precise dose estimations, especially in heterogeneous tissues.