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Age dependence of choroidal blood flow
S Dallinger1, O Findl, K Strenn
1Department of Clinical Pharmacology, Vienna University, Austria.
Journal of the American Geriatrics Society
|April 29, 1998
Summary
Choroidal blood flow decreases with age, indicating increased ocular vascular resistance. This age-related change may contribute to developing common eye diseases like glaucoma and macular degeneration.
Area of Science:
- Ophthalmology
- Vascular Physiology
- Gerontology
Background:
- Choroidal blood flow is crucial for ocular health.
- Age-related changes in vascular function are common.
- Understanding these changes is vital for preventing eye diseases.
Purpose of the Study:
- To investigate the relationship between aging and choroidal blood flow.
- To determine if age affects ocular vascular resistance.
Main Methods:
- Cross-sectional study of 130 healthy volunteers (ages 19-83).
- Measured fundus pulsation amplitude (FPA) using laser interferometry.
- Assessed mean arterial pressure (MAP), intraocular pressure (IOP), and calculated ocular perfusion pressure (OPP).
Main Results:
- Fundus pulsation amplitude (FPA) significantly decreased with age (r = -0.242, P = .005).
- Mean arterial pressure (MAP), intraocular pressure (IOP), and ocular perfusion pressure (OPP) increased with age.
- FPA was associated with age, but not with MAP, IOP, or OPP.
Conclusions:
- Choroidal blood flow is reduced in older individuals.
- Increased ocular vascular resistance is associated with aging.
- This may be a risk factor for age-related macular degeneration and glaucoma.