Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Auxin signalling: protein stability as a versatile control target

O Leyser1

  • 1Department of Biology, Box 373, University of York, York, YO1 5YW, UK. hmol1@york.ac.uk

Current Biology : CB
|May 20, 1998
PubMed
Summary

Two Arabidopsis auxin signaling proteins are homologous to yeast enzymes regulating cell-cycle proteins. This discovery may reveal new insights into plant cell-cycle control and protein stability mechanisms.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Developmental plasticity in plants.

Cold Spring Harbor symposia on quantitative biology·2012
Same author

Auxin regulates SCF(TIR1)-dependent degradation of AUX/IAA proteins.

Nature·2001
Same author

Auxin signalling: the beginning, the middle and the end.

Current opinion in plant biology·2001
Same author

Rapid degradation of auxin/indoleacetic acid proteins requires conserved amino acids of domain II and is proteasome dependent.

The Plant cell·2001
Same author

Summitting the Arabidopsis genome.

Trends in genetics : TIG·2001
Same author

The hormonal regulation of axillary bud growth in Arabidopsis.

The Plant journal : for cell and molecular biology·2000

Area of Science:

  • Plant Molecular Biology
  • Cell Cycle Regulation
  • Biochemistry

Background:

  • Auxin is a key plant hormone regulating growth and development.
  • Cell cycle progression relies on the precise regulation of protein stability.
  • Budding yeast enzymes are known regulators of cell-cycle protein stability, like Sic1p.

Purpose of the Study:

  • To investigate potential homologous relationships between Arabidopsis auxin signaling components and yeast cell-cycle regulators.
  • To explore the functional implications of these homologies for plant cell biology.

Main Methods:

  • Bioinformatic analysis to identify homologous protein sequences.
  • Comparative analysis of protein function in Arabidopsis and yeast.

Main Results:

  • Identified two Arabidopsis auxin signaling pathway components homologous to yeast enzymes.
  • These yeast enzymes are crucial for regulating the stability of cell-cycle proteins, including Sic1p.

Conclusions:

  • The identified homologies suggest a conserved mechanism for regulating protein stability in eukaryotic cell cycles.
  • This finding opens new avenues for understanding auxin's role in plant cell-cycle control.

Related Experiment Videos