Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Typing of malignant mantle zone lymphomas]

B Bednár1

  • 1Hlavův I. patologickoanatomický ústav 1. LF UK a VFN, Praha.

Ceskoslovenska Patologie
|May 1, 1996
PubMed
Summary

Mantle zone lymphomas (ML) diagnosis relies on cytological structure and mantle pattern. Differentiating subtypes requires specific markers like BCL-1 and CD5, impacting treatment and classification.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Expression of beta-catenins and cadherins by follicular dendritic cells in human lymph nodes.

Acta histochemica·2001
Same author

Nonpeptide GPIIB/IIIA receptor antagonists. Part 21: C-6 flexibility and amide bond orientation are important factors in determining the affinity of compounds for activated or resting platelet receptors.

Bioorganic & medicinal chemistry letters·2000
Same author

A reduction in the nursing labor market and its impact on the renal industry.

Nephrology news & issues·2000
Same author

The platelet cytoskeleton regulates the affinity of the integrin alpha(IIb)beta(3) for fibrinogen.

The Journal of biological chemistry·1999
Same author

Fibrinogen receptor antagonist-induced thrombocytopenia in chimpanzee and rhesus monkey associated with preexisting drug-dependent antibodies to platelet glycoprotein IIb/IIIa.

Blood·1999
Same author

Non-peptide GPIIb/IIIa inhibitors. 20. Centrally constrained thienothiophene alpha-sulfonamides are potent, long acting in vivo inhibitors of platelet aggregation.

Journal of medicinal chemistry·1999

Area of Science:

  • Hematopathology
  • Oncology
  • Immunohistochemistry

Context:

  • Mantle cell lymphoma (ML) diagnosis can be challenging due to morphological variations.
  • Accurate subtyping of ML is crucial for prognosis and treatment selection.
  • Existing classification systems may not fully capture the diversity of mantle zone lymphomas.

Purpose:

  • To present diagnostic principles for mantle zone lymphomas based on cytological and immunohistochemical features.
  • To delineate the utility of BCL-1 and CD5 expression in distinguishing ML subtypes.
  • To highlight limitations in current ML classification and coding systems.

Summary:

  • Mantle zone lymphoma (ML) diagnosis primarily relies on mantle pattern and cytological structure.
  • Diffuse mantle zone ML require BCL-1 and CD5 hyperexpression for identification, distinguishing them from BCL-2 positive centrofollicular lymphomas.
  • Plasmacytoid and monocytoid ML variants show distinct BCL-1 and CD5 positivity, complicating precise definition. Nodular ML variants present late and are treatment-resistant, contrary to prior assumptions. Current M-coding for ML is inadequate, failing to differentiate nodular and diffuse forms.

Impact:

  • Improved diagnostic accuracy for mantle zone lymphomas.
  • Enhanced understanding of the immunophenotypic spectrum of ML subtypes.
  • Recommendations for refining ML classification and coding for better clinical management.

Related Experiment Videos