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Dengue surveillance in Metro Manila
M R Capeding1, F J Paladin, E G Miranda
1Research Institute for Tropical Medicine, Alabang, Muntinlupa City, Metro Manila, Philippines.
Summary
This dengue surveillance study in Metro Manila found dengue types 1 and 2 were most common, primarily affecting older children and young adults. Most patients showed secondary antibody responses, with few developing severe dengue shock syndrome.
Area of Science:
- Infectious Diseases
- Virology
- Epidemiology
Background:
- Dengue remains a significant public health concern in tropical regions.
- Effective surveillance is crucial for understanding dengue epidemiology and guiding control strategies.
Purpose of the Study:
- To conduct a one-year surveillance of dengue infection in Metro Manila.
- To identify dengue virus types, patient demographics, clinical manifestations, and associated laboratory findings.
Main Methods:
- Patient enrollment in four Metro Manila hospitals over one year.
- Diagnosis confirmed through virus isolation and serology.
- Clinical and laboratory data collection including antibody response, dengue shock syndrome, thrombocytopenia, and hemoconcentration.
Main Results:
- 143 patients enrolled; 67 diagnosed with dengue.
- Dengue types 1 and 2 were the predominant serotypes isolated.
- Highest incidence observed in older children and young adults.
- Thrombocytopenia (37%) and hemoconcentration (77%) were common; 5 patients had dengue shock syndrome.
- Majority of patients exhibited a secondary antibody response; no fatalities occurred.
Conclusions:
- Dengue types 1 and 2 pose a significant threat to older children and young adults in Metro Manila.
- Clinical and laboratory indicators like thrombocytopenia and hemoconcentration are prevalent.
- Study identified challenges in data quality for future dengue surveillance efforts.