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Mads and Smads in TGF beta signalling
1Department of Anatomy and Cell Biology, University of Toronto, Ontario, Canada.
Current Opinion in Cell Biology
|April 30, 1998
Abstract:
The discovery of the Mothers against dpp (Mad) gene in Drosophila has opened a window on an entirely unique signalling pathway that functions to mediate responses to the tumour growth factor beta (TGF beta) superfamily. This pathway, which is comprised of a family of proteins related to Mad, acts to convey signals directly from TGF beta receptors to the nucleus and is implicated in the pathogenesis of human diseases.