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Oxygen radicals and signaling

T Finkel1

  • 1Cardiology Branch, National Institutes of Health, Bethesda, MD 20892-1650, USA.

Current Opinion in Cell Biology
|April 30, 1998
PubMed
Summary

Reactive oxygen species act as cellular signals, influencing various biological processes. This review explores how these oxidants are generated and involved in redox regulation within cells.

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Area of Science:

  • Cellular Biology
  • Biochemistry
  • Signaling Pathways

Background:

  • Reactive oxygen species (ROS), including superoxide anions and hydrogen peroxide, are increasingly recognized for their roles beyond oxidative damage.
  • Evidence points to ROS functioning as critical intracellular second messengers in cellular communication.

Purpose of the Study:

  • To review the current understanding of intracellular pathways involved in ROS generation.
  • To discuss the expanding list of cellular processes regulated by ROS and redox signaling.

Main Methods:

  • Literature review of recent studies on ROS generation and function.
  • Analysis of signaling cascades leading to oxidant production.
  • Examination of cellular processes affected by redox regulation.

Main Results:

  • Detailed pathways from ligand stimulation to ROS production are being elucidated.
  • A growing number of cellular functions, from proliferation to apoptosis, are shown to be under redox control.
  • ROS act as key signaling molecules, not just byproducts of metabolism.

Conclusions:

  • ROS are integral components of intracellular signaling networks.
  • Understanding redox regulation is crucial for comprehending diverse cellular functions and potential therapeutic targets.

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