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Langerhans cell histiocytosis research. Past, present, and future

C Nezelof1, F Basset

  • 1Department of Pathology, Faculté de Médecine de Paris, France.

Hematology/Oncology Clinics of North America
|April 30, 1998
PubMed

This article reviews the various investigative events that led to the endorsement of the term Langerhans cell histiocytosis for the various clinicopathologic conditions previously called Hand-Schüller-Christian disease, Abt-Letterer-Siwe disease, eosinophilic granuloma of bone, and histiocytosis X. The different denominations reflect the changing conceptual approaches to the so-called reticuloendothelial system and the successive acquisition of new ultrastructural and immunocytochemical data.

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