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Direct Intrathecal Injection of Recombinant Adeno-associated Viruses in Adult Mice
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Direct Intrathecal Injection of Recombinant Adeno-associated Viruses in Adult Mice

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[Intrathecal interferon therapy in chronic echovirus meningoencephalitis in Bruton type agammaglobulinemia]

A von der Wense1, B Herrmann, R Deppermann

  • 1Kinderklinik der Städtischen Kliniken Kassel.

Klinische Padiatrie
|April 30, 1998
PubMed

A 9-year-old body with X-linked agammaglobulinemia developed chronic enteroviral meningoencephalitis (CEMA) caused by echovirus type 6. Intravenous treatment with selected immunoglobulin charges containing high titers against echovirus type 6 or combination with beta-interferon did not result in improvement. After implantation of a Rickham reservoir and periodical administration of intraventricular and intravenous immunoglobulin the virus recurred rapidly each time treatment was stopped. After 20 months of treatment the patient received a combined therapy with beta-interferon and selected immunoglobulin. Both drugs were given by lumbar puncture, intravenously and via Rickham reservoir. Subsequently echovirus type 6 could not be isolated in culture or PCR. Cerebrospinal fluid pleocytosis disappeared. The remission is lasting for more than three years. Intrathecal and intraventricular beta-interferon therapy for CEMA is being reported for the first time. Facing the unfavourable prognosis of the disease this mode of treatment is a new therapeutic approach following failure of other therapies.

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