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Cold-induced thermoregulation and biological aging

M Florez-Duquet¹, R B McDonald

¹Department of Nutrition, University of California, Davis, USA.

Physiological Reviews

|April 30, 1998

Summary

Aging impairs the body's ability to regulate temperature in the cold, a process called cold-induced thermoregulation (CIT). This decline is due to increased heat loss and reduced metabolic heat production, but the exact mechanisms require further study.

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Area of Science:

Gerontology
Physiology
Thermoregulation

Background:

Aging is linked to reduced cold-induced thermoregulation (CIT).
Mechanisms likely involve increased heat loss and decreased metabolic heat production.
The precise causes of diminished CIT in aging remain unclear.

Purpose of the Study:

To review the current understanding of age-related changes in cold-induced thermoregulation.
To explore the potential mechanisms behind diminished CIT in older adults.
To discuss how CIT alterations may inform the study of biological aging.

Main Methods:

Literature review of studies on aging and thermoregulation.
Analysis of evidence for increased heat loss (cutaneous vasculature, body fat).
Examination of evidence for decreased metabolic heat production (skeletal muscle shivering, brown adipose tissue nonshivering thermogenesis).

Main Results:

Aging reduces the ability to conserve heat through cutaneous vasoconstriction.
Skeletal muscle shivering and brown adipose tissue nonshivering thermogenesis decrease with age.
Reduced brown fat thermogenesis may stem from altered cellular signaling.

Conclusions:

Cold-induced thermoregulation declines with chronological aging.
The exact mechanisms underlying this decline are not fully elucidated.
A clearer definition of biological aging is needed to fully understand CIT changes.

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