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Vascular permeability factor/vascular endothelial growth factor and vascular stroma formation in neoplasia. Insights
L F Brown1, A J Guidi, K Tognazzi
1Departments of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA.
Abstract:
The formation of vascular stroma plays an important role in the pathophysiology of malignancy. We describe the use of in situ hybridization in our laboratory as a tool to study the role of vascular permeability factor/vascular endothelial growth factor in the angiogenesis associated with malignancy.