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Related Experiment Videos

Diabetic peripheral neuropathy

D S Younger1, G Rosoklija, A P Hays

  • 1Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York, USA.

Seminars in Neurology
|May 1, 1998
PubMed
Summary
This summary is machine-generated.

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Diabetic neuropathy, a complication of diabetes mellitus, involves nerve damage often caused by microangiopathy. While glycemic control helps, intravenous immune globulin may benefit selected patients with progressive syndromes.

Area of Science:

  • Neurology
  • Endocrinology
  • Pathology

Background:

  • Diabetes mellitus frequently causes clinicopathologic neuropathic syndromes.
  • Diagnosis involves history, neurologic examination, electrodiagnostic studies (EMG), and potentially biopsy.
  • Microangiopathy is the primary cause, linked to metabolic, immunologic, or ischemic injury.

Observation:

  • Tight glycemic control and symptomatic treatments offer partial benefits but don't halt neuropathy progression, especially with severe motor/gait impairment.
  • Intravenous immune globulin (IVIG) presents a novel therapeutic option for diabetic neuropathy.
  • IVIG consideration is for carefully selected patients with specific progressive syndromes, confirmed by comprehensive studies.

Findings:

  • Diabetic neuropathy encompasses various syndromes.

Related Experiment Videos

  • Microvascular changes are central to diabetic neuropathy pathogenesis.
  • Advanced diagnostic methods are crucial for identifying eligible patients for novel therapies like IVIG.

    • Implications:

    • Early and accurate diagnosis of diabetic neuropathy is essential.
    • Comprehensive patient characterization is key for effective treatment selection.
    • Intravenous immune globulin shows promise for specific, progressive forms of diabetic neuropathy.