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Related Experiment Videos

Cryptogenic sensory and sensorimotor polyneuropathies

G I Wolfe1, R J Barohn

  • 1Department of Neurology, University of Texas Southwestern Medical Center, Dallas 75235-8897, USA.

Seminars in Neurology
|May 1, 1998
PubMed
Summary
This summary is machine-generated.

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Chronic sensorimotor polyneuropathy often remains unclassified, typically affecting older adults with slow-progressing symptoms like pain. Most cases are axonal, with a favorable prognosis and minimal motor disability, emphasizing management through pain therapy and patient education.

Area of Science:

  • Neurology
  • Clinical Neuroscience

Background:

  • Chronic sensory or sensorimotor polyneuropathy is a frequent neurological referral.
  • A significant portion, up to one-third, remains unclassified despite advanced diagnostics.

Purpose of the Study:

  • To provide insight into the clinical spectrum and course of chronic polyneuropathies.
  • To characterize the typical presentation, progression, and prognosis of these conditions.

Main Methods:

  • Review of recent studies on clinical spectrum and course.
  • Analysis of clinical, electrophysiologic, and histologic findings.
  • Evaluation of patient presentation, symptom progression, and long-term outcomes.

Main Results:

  • Onset typically occurs in the sixth to seventh decades of life.

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  • Symptoms, primarily paresthesias or pain, progress slowly.
  • Unclassified polyneuropathies are predominantly axonal.
  • Prognosis is generally favorable, with rare progression to significant motor disability or incapacitation.

    • Conclusions:

    • Management should prioritize pharmacotherapy for painful paresthesias.
    • Patient education and reassurance are crucial components of care.
    • Chronic polyneuropathy, even when unclassified, rarely leads to severe functional impairment.