Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Antiepileptics]

J Overweg1

  • 1Instituut voor Epilepsiebestrijding Meer en Bosch, De Cruquiushoeve, Heemstede.

Nederlands Tijdschrift Voor Geneeskunde
|May 1, 1998
PubMed
Summary

Established antiepileptic drugs remain effective for most epilepsy patients. Newer antiepileptic drugs offer improved combination therapy options with fewer interactions, pending cost-benefit analysis.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The organization and utilization of a case register on epilepsy.

International journal of adolescent medicine and health·2012
Same author

Installation of the 1.5 T MRI accelerator next to clinical accelerators: impact of the fringe field.

Physics in medicine and biology·2009
Same author

Integrating a 1.5 T MRI scanner with a 6 MV accelerator: proof of concept.

Physics in medicine and biology·2009
Same author

Eight-channel transmit/receive body MRI coil at 3T.

Magnetic resonance in medicine·2007
Same author

A multicenter, randomized clinical study to evaluate the effect on cognitive function of topiramate compared with valproate as add-on therapy to carbamazepine in patients with partial-onset seizures.

Epilepsia·2000
Same author

Prospective study of the prevalence of Alzheimer-type dementia in institutionalized individuals with Down syndrome.

American journal of mental retardation : AJMR·1997

Area of Science:

  • Neurology
  • Pharmacology

Context:

  • Epilepsy treatment relies on established drugs like phenytoin, carbamazepine, and valproate, effective in about two-thirds of patients.
  • A significant portion of patients (20-60%) show resistance to these older antiepileptic drugs.

Purpose:

  • To review the efficacy and utility of newer antiepileptic drugs (AEDs) in epilepsy management.
  • To compare the benefits and drawbacks of established versus novel AEDs, including their impact on combination therapy.

Summary:

  • Established AEDs are first-line treatments for epilepsy.
  • Newer AEDs, including ethosuximide, clobazam, and topiramate, can reduce seizure frequency by 50% in drug-resistant cases when added to classic treatments.
  • Many new AEDs lack the enzyme-inducing properties of older drugs, simplifying monotherapy and combination therapy.

Impact:

  • Newer AEDs offer improved therapeutic options, particularly for treatment-resistant epilepsy.
  • The widespread adoption of new AEDs will hinge on comprehensive cost-benefit analyses, considering efficacy, side effects, drug interactions, and teratogenicity.

Related Experiment Videos