Related Experiment Video
Updated: Aug 8, 2026
09:05
Determining the Phagocytic Activity of Clinical Antibody Samples
Published on: November 30, 2011
[Immunology in clinical practice. X. IgG receptors: structure, function and immunotherapy]
W L van der Pol1, J G van de Winkel
1Afd. Immunologie, Academisch Ziekenhuis, Utrecht.
Nederlands Tijdschrift Voor Geneeskunde
|May 1, 1998
Summary
Immunoglobulin G (IgG) receptors (Fc gamma R) link humoral and cellular immunity, driving immune responses and regulating IgG levels. Targeting these receptors shows promise in cancer immunotherapy.
Area of Science:
- Immunology
- Molecular Biology
- Cell Biology
Context:
- Fc gamma receptors (Fc gamma R) bridge the humoral and cellular immune systems.
- These receptors are expressed on various immune cells, including leukocytes and endothelial cells.
- Soluble Fc gamma R in plasma modulate immune system activity.
Purpose:
- To elucidate the diverse functions of Fc gamma receptors in immune responses.
- To highlight the role of Fc gamma R in IgG regulation and transport.
- To explore the therapeutic potential of Fc gamma R-mediated functions in cancer treatment.
Summary:
- Fc gamma R on leukocytes mediate key immunological effector functions like phagocytosis and antibody-dependent cellular cytotoxicity (ADCC).
- Fc gamma R on endothelial cells (Brambell receptor: FcRB) regulate blood IgG levels and maternal IgG transfer to fetuses.
- Soluble Fc gamma R act as modulators within the immune system.
Impact:
- Understanding Fc gamma R functions is crucial for comprehending immune system regulation.
- Fc gamma R-targeted experimental immunotherapies demonstrate significant potential against hematological and solid tumors.
- This research provides a foundation for developing novel immunotherapeutic strategies.
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01:10Antibody Structure
Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
00:42Cross-reactivity
Overview
01:10Antibody Structure
Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
01:15Transcytosis of IgG
Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
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Antibodies, also known as immunoglobulins, are produced by B cells in response to foreign substances, such as bacteria and viruses. These proteins are critical for recognizing and neutralizing these substances, protecting the body from potential harm.
The basic structure of an antibody consists of four protein chains: two identical heavy chains and two identical light chains. These chains are held together by disulfide bonds and other non-covalent interactions, forming a Y-shaped structure.
The basic structure of an antibody consists of four protein chains: two identical heavy chains and two identical light chains. These chains are held together by disulfide bonds and other non-covalent interactions, forming a Y-shaped structure.
01:27Tumor Immunotherapy
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.