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Subnormal tissue 3 alpha-androstanediol and androsterone in prostatic hyperplasia

A W Meikle, J D Stringham, D C Olsen

The Journal of Clinical Endocrinology and Metabolism

|October 1, 1978

Summary

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This study found 3 alpha-androstanediol (3 alpha-diol) levels were lower in benign prostatic hyperplasia (BPH). The findings suggest DHT formation, not 3 alpha-diol, may be linked to prostate growth in aging men.

Area of Science:

Endocrinology
Urology
Biochemistry

Background:

Benign prostatic hyperplasia (BPH) is a common condition in aging men.
The role of androgens, including 3 alpha-androstanediol (3 alpha-diol) and 5 alpha-dihydrotestosterone (DHT), in BPH development is not fully understood.
Enzymatic metabolism of androgens in prostatic tissue is critical for understanding BPH pathogenesis.

Purpose of the Study:

To investigate the role of 3 alpha-diol in BPH development.
To examine the equilibrium of enzymes metabolizing 3 alpha-diol in normal and hyperplastic prostate tissue.
To determine androgen concentrations in normal and BPH human prostate glands.

Main Methods:

Radioimmunoassay (RIA) was used to quantify endogenous concentrations of 3 alpha-diol, androsterone, and DHT.

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Androgens were extracted and purified using paper chromatography from normal and hyperplastic prostate tissues.

Statistical analysis was performed to compare androgen levels and ratios between normal and BPH groups.

Main Results:

Mean concentrations of 3 alpha-diol and androsterone were approximately one-third lower in BPH tissue compared to normal tissue.
The ratio of DHT to 3 alpha-diol concentration was significantly higher in BPH (P < 0.005).
No significant difference was found in the ratio of 3 alpha-diol to androsterone between normal and BPH tissues.

Conclusions:

The study data do not support a causal relationship between 3 alpha-diol and BPH development.
The results suggest that the enzymatic equilibrium favors DHT formation, which may be relevant to prostate growth in aging men.
Further research into androgen metabolism and its role in prostate health is warranted.